Best Liver Supplement | Seattle Weekly


The liver is the largest solid organ in the body and should not be taken lightly. Matter-of-factly, when it fails to function as required, toxins will remain in the body’s blood supply, blood sugar levels will drastically fluctuate, the risk of blot clots is likely to rise, and other vital functions will come to an end [1]. Sometimes a tiny tweak is all that’s needed to revamp one’s system. In the case of the liver, it may be in the form of detoxification. How does one go about stimulating this process? Well, our editorial team further analyzed an array of solutions, of which supplements appear to have the best response.

The question now becomes which of the thousands of liver detox supplements individuals should go with. The purpose of this comprehensive guide is to shed light on 2022’s most in-demand liver supplements. Throughout this process, our team will cover the basics of the top picks, the reason(s) why they made the list, the scientific narrative, and how best to differentiate successful solutions from those that offer nothing more than fillers. Above all, this guide will unlock the door to the endless possibilities that stem from considering natural ingredients, not to forget the load that will be immediately lifted from one’s back!

Getting to Know The Best Liver Supplements of 2022

As mentioned earlier, the liver detox supplements market is quite flooded, and it can be challenging to decide which ones to go with. Fortunately, we managed to narrow down on the best offerings, and weed out some of the less-deserving options. Bear in mind that these picks are based on several factors and not simply on their ingredients or user reports. Without further ado, here is our list:

Oweli Liver Detox


Oweli Liver Detox focuses on a natural detox mechanism. It is a reputable brand that uses the proven efficiency of antioxidants and minerals to create a powerful and balanced blend of herbal extracts and minerals. The scientifically formulated mix plays a vital role in making detoxification efficient.

Oweli includes effective natural ingredients like milk thistle, which is a powerful antioxidant. Milk thistle flushes the toxins out of the body and minimizes oxidative stress. Other antioxidants present in the natural herb mix include beetroot, chicory root, and chanca piedra. Along with these powerful antioxidants, the detox mix contains artichoke extract and dandelion, which helps purge toxin levels and reduce stress on the liver.

Oweli Liver Detox offers complete quality and safety control and ensures the product free of pesticides or any other harmful pathogen. It is manufactured in pharmaceutical-grade facilities that are FDA-registered and compliant with cGMP standards. The product has zero synthetic additives or GMOs and is backed by a 100-day money-back guarantee, which makes it one of the more trustworthy brands in the market.

Price: $29.99

Advanced Liver Support

  • Company: Advanced Bionutritionals
  • Starting Price: $39.95

Advanced Liver Support has been formulated with the entire body in mind. According to Advanced Bionutritionals, it is essential to support other organs while also targeting the liver. As a result, the team insists that they’ve created a solution that helps keep the brain and liver, increases enzyme production essential for fighting against oxidative stress, and promotes optimal adrenal glands’ function. Most importantly, the selected ingredients are reckoned to stimulate the liver’s natural detoxification processes.

As a company touted for its “cutting-edge line of nutraceuticals,” Advanced Bionutritionals claims to have taken the necessary steps in ensuring that only fresh, quality ingredients were used during the manufacturing processes. The selling point for this company is the coming together of healthcare experts who have developed various solutions to date. Every serving (4 capsules) constitutes the effects of Selenium (50mcg), Phosphatidylcholine (125mg), Agaricus blazei Murill fruit body (200mg), Licorice (1000mg), Milk Thistle (100mg), Quercetin (250mg), Alpha Lipoic Acid (100mg), and N-Acetyl-L-Cysteine (75mg).

Complete Liver Support

  • Company: Gundry MD
  • Starting Price: $19.48

Complete Liver Support is believed to regulate the body’s nutrient absorbing capacities, increase energy levels, and promote a healthy digestive system. Together, these facets can give rise to a bodily defense that can protect all cells and organs from the effects of environmental toxins. For those wondering why Gundry MD, the company was founded by the renowned Dr. Steven Gundry, who is presently on a mission to help improve human health, happiness, and longevity.

Having spent decades as a cardiac surgeon, further research led him towards natural supplements, allowing him to explore a different health stream. After 12 years of studying the human microbiome, Dr. Gundry developed a series of products that remain a customer favorite. Nevertheless, the Complete Liver Support formula embodies simplicity. Precisely, each serving delivers Orange Peel Extract (1000mg), Milk Thistle (175mg), and Dandelion Root Extract (150mg).


  • Company: 1MD
  • Starting Price: $40.99

LiverMD is advertised as a scientifically formulated liver support that delivers two “clinically effective” ingredients. Consequently, individuals can anticipate healthy liver enzyme function and detoxification, increased energy levels, and proper cell division within the liver. Additional components have been included to ensure superior absorption insists 1MD. Speaking of the company responsible for this potent formula, 1MD is physician-formulated and is devoted to helping consumers achieve results in the most effective ways.

In keeping with everything that has been discussed thus far, we can say with certainty that 1MD focused on the philosophy, “simple is sweet.” In other words, each serving contains Vitamin E (3.5mg), Zinc (15mg), Selenium (200mcg), Siliphos® (80mg), N-Acetyl-Cysteine (800mg), and Alpha Lipoic Acid (100mg). It does lack some of the promising botanicals found in other liver support options.

Liver Reset

  • Company: Organifi
  • Starting Price: $27.95

Liver Reset naturally supports the liver made entirely of superfoods. This supplement is for anyone in dire need of daily liver support, fat loss, detoxifying power, and maximum digestion, among others. Founder, Drew Canole, was once overweight, tired, and unhappy with his life. When he decided to take the path towards transformation, his go-to was superfoods. As he continued his journey and re-watched everything he shared online, he realized that many people need guidance. This is what led him to establish Organifi, an ultimate superfood brand. He affirms that “over one million people have already felt the impact of Organifi, and this is only the beginning.”

Commenting on the power of superfoods, Liver Reset has been formulated with Organic Triphala (300mg), Organic Dandelion (300mg), Organic Milk Thistle (250mg), and Artichoke Extract (150mg).

Liver Health Formula

  • Company: PureHealth Research
  • Starting Price: $44.10

The Liver Health Formula has been developed to prevent consumers from falling into a series of health traps, including fluctuating blood sugar levels, heart and kidney issues, weight gain, excessive bleeding, and high brain pressure to say the least. To ensure that the liver stops itself from overworking, namely, having to fight against oxidative stress and environmental stressors, a simple formula has been considered. In doing so, liver markers and other bodily functions are likely to be improved.

Regarding PureHealth Research’s strategies, they involve sitting down with the advisory board of doctors and health professionals, all of whom must give their stamp of approval before issuing solutions to the market. This led the team to include Turmeric (300mg), Beet Root (200mg), Dandelion (100mg), Milk Thistle (50mg), Artichoke Extract (50mg), Ginger (50mg), Alfalfa (20mg) and L-Cysteine (10mg) in each Liver Health Formula serving.

Liver Support

  • Company: Amy Myers MD
  • Starting Price: $29.72

Liver Support is reckoned to help attain optimal liver function, bile production, and maximum detoxification. In addition, each serving is believed to act as a potent free radical scavenger while protecting the liver right down to its cells. To fully understand this formula, individuals need to understand the brand, i.e., Amy Myers MD. Hinted in the name, Dr. Myers is the founder of this brand and is a formally trained physician who helped thousands of patients with autoimmune, thyroid, and digestive issues.

Who can forget the fact that Dr. Myers is someone who also overcame health consequences the natural way? Therefore, she decided it only made sense to educate consumers. Taking everything into account, the Liver Support formula embodies the power of Selenium (100mcg), Milk Thistle (262.5mg), Alpha Lipoic Acid (200mg), and N-Acetyl-L-Cysteine (200mg).

Liver Support Plus

  • Company: VitaPost
  • Starting Price: $27.95

VitaPost created Liver Support Plus to assist the liver naturally. With this supplement, our hardworking organ is trusted to perform at its best, detoxifying the body, eliciting metabolic processes, or the other 500 roles it has been tasked with. To ensure the latter is possible, the team at VitaPost affirms to have put each product through an academic and scientific substantiation process. Forget competition for a second, as VitaPost focuses more so on what consumers deserve: “freedom to try all kinds of exotic formulations, drawing from botanical wisdom accumulated over thousands of years.”

Regarding ingredients, each serving is said to deliver Zinc (30mg), Milk Thistle (200mg), Beet Root (50mg), Artichoke Extract (50mg), Chanca Piedra Extract (50mg), Dandelion (50mg), Chicory Root (50mg), Yarrow (50mg), Jujube Seed (50mg), and a proprietary blend of 546mg. Mainly, the proprietary blend makes up Celery Seed, Alfalfa, Burdock Root, Yellow Dock, Methionine, Grape Seed Extract, L-Cysteine, Feverfew, N-Acetyl-Cysteine, Choline, Turmeric, Red Raspberry, Berberine and Ginger.


  • Company: Live Conscious
  • Starting Price: $25.99

LiverWell is an all-natural supplement that combines a series of ingredients that have been clinically proven to aid both kidney and liver functions. In particular, this formula aims to enhance both detoxifying power and the reparative strength of the duo organs. Those who wonder how the liver and kidney work together turn out that the liver breaks down harmful substances while the kidneys filter out the remaining blood by-products.

At Live Conscious, the goal is to create traditionally sourced, clinically proven products that can balance the mind, body, and spirit. As explained by the team, “whether we’re concocting a vitamin, probiotic, or protein powder, we are focused on creating natural products that have the greatest potential to revolutionize your wellbeing.” With such a mission and emphasis on not one but two organs, individuals would assume that the formula would be pretty in-depth, but it is quite the opposite. Precisely, each serving combines the effects of Zinc (15mg), Selenium (200mcg), Siliphos® (80mg), N-Acetyl Cysteine (800mg), and Alpha Lipoic Acid (100mg).

Morning Complete

  • Company: ActivatedYou
  • Starting Price: $79

Morning Complete is a dietary supplement that fortifies the body with essential nutrients trusted to revamp the metabolism and energy levels, regulate blood sugar levels, and increase feelings of nourishment. Each serving is formulated in apple cinnamon flavor and is said to deliver prebiotics, probiotics, and energy nutrients. Unfortunately, the ingredient list has not been provided at the time of writing, which is a shame since this supplement is popularly in demand.

Another issue our team has with this one is not having a company background like the rest of the solutions. Together, it makes us wonder why the set prices are the way they are. This is sure to raise concerns for consumers, so we ask everyone to contact customer service for more clarity before placing an order.

Urgent Liver 911

  • Company: Phytage Labs
  • Starting Price: $69.95

Urgent Liver 911 is a dietary supplement specifically designed to target a toxic liver, flush out fat known to clog the liver, and possibly repair and protect the liver from future hindrances. As for the company behind this solution, Phytage Labs prides itself in delivering high-quality ingredients and is committed to quality, which to them is “neither cheap nor easy to do.” They have considered 23 components altogether, which in our opinion resembles that of VitaPost’s approach.

To be more precise, each serving entails Zinc (30mg), Milk Thistle (200mg), Beet (50mg), Artichoke (50mg), Chanca Piedra (50mg), Dandelion (50mg), Chicory (50mg), Yarrow (50mg), Jujube Seed (50mg) and a proprietary blend of 586mg. The latter constitutes Celery Seed, Alfalfa, Burdock Root, Yellow Dock, Methionine, Grape Seed Extract, L-Cysteine, Feverfew, N-Acetyl-Cysteine, Choline, Turmeric, Red Raspberry, Berberine and Ginger.

Zenith Detox

  • Company: Zenith Labs
  • Starting Price: $49

Zenith Detox is intended to support liver health while emphasizing the two supposed phases of detoxification. In so doing, the body will have been scavenged and eliminated from free radicals and then protected from harmful toxins. Who can forget one’s ability to finally overcome slumps, brain fogs, achy joints, and insufficient stamina, among others? One word to describe this formula is “complete,” as the results entail a complete body transformation.

Zenith Labs being a research-based nutrition provider, we can expect to see ingredients with traditional and scientific substances. Hence, each serving is trusted to deliver a considerable amount of Vitamin B6 (25mg), Folic Acid (100mcg), Vitamin B12 (100mcg), Magnesium (50mg), L-Methionine (300mg), Choline (200mg), Setria Glutathione (150mg), Milk Thistle (150mg), N-Acetyl-L-Cysteine (100mg), Bupleurum Root Powder (100mg), Artichoke (100mg), Dandelion (50mg), Celandine Herb (50mg), Beet (50mg), Broccoli (50mg), Green Tea (50mg), Schisandra Berry (50mg), Taurine (50mg), Picrorhiza Root (50mg).

Bonus Guide: The Non-Alcoholic Fatty Liver Disease Solution

  • Company: Blue Heron Health News
  • Starting Price: $49

Unlike the above-listed solutions delivered in the form of supplements, the Non-Alcoholic Fatty Liver Disease Solution is a guide that expounds on means to help free individuals from fatty liver disease. As stated on the official website, three pillars need to be mastered to restore the liver’s poise. When the included tips are followed to the tee, individuals can anticipate total health and vitality, explains the author, Jennifer Williams. When we saw this guide, we couldn’t stop but wonder to what extent the tips provided are unique compared to the types that are one search engine away. Fortunately, the only way to find out is by placing an order.

The Ultimate Ranking System

Liver detox supplements easily outnumber all other categories, and to be able to simplify the list to our picks requires a lot of thought process. Our editorial team had to consider the reason for existence and whether set goals were met. Additional factors were reflected upon to ensure purity, quality, and effectiveness, among others. In other words, we were able to put our thoughts together in the following ranking system:

Ingredients List

The all-natural approach to healing our bodies has been around for as long as centuries can recount. However, they’ve only made it to mainstream media in recent times. So, we are aware that scientific evidence on certain ingredients is likely lacking. However, many components have been proven to have a positive, lasting impression on the liver. We were curious to see whether supplement providers caught on and implemented them in their formulas.

Effective Dosages

Following from the ingredients list is the significance of effective dosages. In most studies, animals and humans are administered a specific dosage to see how much impact can be witnessed. If, for instance, 100mg of Milk Thistle daily has been proven to stimulate desirable results, then we want to see that in the supplement facts. Trying to cut back on concentration is meaningless for healing purposes and would not justify value for the price.

Company Background & Transparency

A solution is nothing without the science behind it, and this signifies the role that the company plays. More than role, it reflects the mission, thought processes, foundation, and formulation that makes certain manufacturers a better choice than others.. When a supplement is neither backed by a company nor meets high transparency levels, it worries consumers. Why would anyone take a supplement when the team isn’t standing by it? How about the case where the team fails to guide individuals from the supplement’s start to end? Sometimes individuals tend to lean towards a popularly in-demand product. Still, it could go both ways: a product can either be proven effective and, hence, attract consumers or may have risen to fame because of word of mouth.

Suggested Benefits

The purported benefits are an easy way to differentiate scams from legitimate products. It boggles us to see outrageous health claims deemed achievable within a matter of days or weeks. When researching a particular ingredient, we like to summarize the results and the science backing it, and compare them to what a company says its solutions can do. If they affirm that a highly damaged liver can be revamped from day one, individuals need to stop and wonder how much truth rests in such a statement.

Value for Money

Value for money is the factor that ties everything together. We’ve noticed several products that lack the right ingredients and dosages yet somehow are charging ridiculously high prices. A good liver supplement product shouldn’t break the bank. Our consensus is if the price encompasses many of the above factors, then it is worthwhile. Otherwise, individuals are left with a money-grab reflecting limited health benefits.

Bringing Science to the Table: What’s in Store Regarding Existing Evidence?

We’ve come to the most crucial part of the guide, i.e., the discoveries made by the scientific community. By simply skimming through our top picks, individuals are likely to be exposed to over 20 unique ingredients deemed effective at revamping the liver. But are they equally and genuinely effective? This is where our research comes into play. To give everyone a sense of the process, the following summary will include the top five ingredients found across all the listed supplements. Let’s get started!


Selenium is a type of trace mineral that allegedly supports several bodily processes. One source insists that selenium deficiency in the blood, hair and nail clippings is linked to the risk of developing cancer. The known types include lung, bladder, stomach, esophagus, and liver. A meta-analysis of nine controlled clinical trials was also reported, where the researchers concluded that a high selenium level could reduce the latter risks [2]. Selenium deficiency is deemed rare among Americans. Another source insists that too much selenium can lead to liver problems, including non-alcoholic fatty liver [3]. All-in-all, we were hoping to find more studies, but this ingredient has not been studied extensively enough.

Milk Thistle

Milk thistle is a flowering herb deemed a nice balance between the daisy and ragweed families. One review that looked to summarize the effects of milk thistle, or more specifically, its main compound, Silybum, highlighted that the latter’s “antioxidant activity, toxin blockade at the membrane level, enhanced protein synthesis, antifibrotic activity, and possible anti-inflammatory effects” might be hepatoprotective. Some of the main benefits reported across various studies include improved liver function (i.e., aminotransferases, albumin, and malondialdehyde).

However, mixed results cannot be ignored, which stem from poor study design, unclarity, and nonsignificant effect sizes [4]. Many sources have expressed the latter, one of them being WebMD, where it was noted that “there’s conflicting research on the benefits […] It may have protective effects on the liver preventing damage. There’s some evidence that milk thistle can treat cirrhosis and hepatitis [but] experts say that the evidence isn’t conclusive. [5]”


Dandelion is a plant with yellow flowers, where the flowers and the leaves, stems, and roots are used for medicinal purposes. According to current findings, it is believed that dandelions are filled with polysaccharides, essential for reducing stress imposed on the liver. In turn, this is trusted to help with the liver’s ability to effectively produce bile, filter out harmful chemicals, and ensure maximum absorption [6]. Interestingly, another source highlighted dandelion as a crucial component in folk medicine and has thus far helped with skin and liver function [7], even if these results stem from preliminary studies.

Alpha Lipoic Acid

Alpha-lipoic acid is a naturally occurring compound celebrated for its abundance of antioxidants. One study that looked at the impact of alpha-lipoic acid on liver function and metabolic markers in obese patients with the non-alcoholic fatty liver disease found evidence of possible benefits on insulin resistance and metabolic disorders. While it did not significantly affect the liver, factors about insulin were positively impacted [8]. Nonetheless, this is important, seeing that insulin resistance can force lipids to accumulate on the liver.

N-Acetyl Cysteine

N-Acetyl Cysteine is a dietary supplement that stems from L-cysteine, i.e., an amino acid. As an antioxidant, this respective ingredient can reduce DNA damage while ensuring liver-protective properties that support healthy immune function [9]. A study that aimed to investigate the role N-Acetyl Cysteine plays in liver health reported a significant decrease of serum alanine aminotransferase (i.e., a liver marker) after three months, affirming that its inclusion can improve liver function in patients with non-alcoholic fatty liver disease, adding that “better results may be achievable in a longer follow up [10].”

Frequently Asked Questions (FAQS) about Liver supplements

What is the purpose of a liver supplement?

Liver supplements are formulated with several purposes in mind. For instance, they are trusted to protect liver cells from inflammation, may promote bile production, and are likely to trigger healthy detoxifying to free the liver from immense stress [11].

What is the significance of bile production?

Bile contains acids essential for digestion and absorption of fats and fat-soluble vitamins within the small intestine. Many body waste products are eliminated and secreted into bile through urine and feces [12].

Is it safe to take liver supplements?

Liver supplements are generally safe to take because they are filled with plants, herbs, vitamins, minerals, and other nutrients. That said, seeking expert advice (i.e., health practitioner) is the best way to go about liver supplements, especially for pregnant and nursing mothers and people with a history of medical conditions.

What are the responsibilities of the liver?

The main functions of the liver are to regulate chemical levels in the blood and to excrete bile. As mentioned above, bile is a crucial element in carrying out waste from the body [12].

What factors give rise to liver damage?

According to the Mayo Clinic, liver damage results from poor lifestyle choices and medical conditions. Precisely, heavy alcohol use, obesity, type 2 diabetes, tattoos, prescription drugs, and unprotected sex, to say the least, can negatively influence the liver’s overall performance [13].

Is liver disease genetic?

Yes, liver disease can be inherited; however, that’s not the only way to be diagnosed with liver diseases. Please refer to the factors mentioned above that give rise to liver damage.

What signs indicate severe liver damage?

Some signs of severe liver damage include jaundice, pain in the upper right abdomen, ascites, nausea, vomiting, a general sense of sickness, confusion, lack of sleep, musty or sweet breath, and tremors. People who experience any one of these signs should immediately seek medical attention [14].

Is detoxifying the liver helpful?

One source affirms that detoxes aren’t as important when it comes to how the liver functions. There supposedly isn’t any proof suggesting that toxins can be eliminated from the body. However, the type of detox that is important is one that naturally drives the liver. The liver is a natural detoxifier, and triggering this function ensures wellness [15].

What are some healthy strategies for protecting the liver?

Several health experts have recommended healthy strategies globally, and the beauty that rests in these recommendations is founded on simplicity. Specifically, individuals can consider steps to maintaining a healthy weight, a balanced diet, regular exercise, consuming alcohol moderately, avoiding drug use and contaminated needles, and getting medical assistance when things feel uneasy [16].

Is it possible to reverse liver damage?

Yes, it is possible to reverse liver damage because the liver can repair itself completely when given the opportunity. The reason why things may feel like they are falling apart is when the liver becomes exhausted. In general, the best results come to those who make appropriate lifestyle choices, all while seeking help when required [17].

What dietary requirements should be followed for a healthy liver?

When it comes to eating a balanced diet for the liver, better yet, one’s entire wellness, individuals are asked to consider appropriate portions of grains, fruits, vegetables, meat and beans, and oil. Foods high in fiber are also recommended for optimal liver function [18].

The Best Liver Supplement of 2022 Final Verdict

Ultimately, liver supplements are created to support liver function, restore it, repair it, or enhance its function. Given that this organ is the largest and most complex working of the bunch, having such supplements may help keep things grounded. Not all natural ingredients deemed “liver-transforming” have been supported by scientific evidence. This is the main reason why supplements are generally considered as an add-on and never the primary solution.

Comparing Top Liver Products At A Glance

Oweli Liver Support Best Overall Formulation
Advanced Liver Support Best Value
Gundry Complete Liver Most Doctor-Recommended
LiverMD Best Customer Support
Organifi Liver Rescue Most Popular with Users

Before anything, we hope consumers will take the time to reflect on their health, possibly with a health practitioner, before taking liver detox supplements. Such a first step is fundamental in protecting the entire body and preventing side effects from taking over. Until we update our top picks for the next year, we encourage everyone to question products actively. The quality of answers will help distinguish effective solutions from their weaker counterparts!


The news and editorial staff of Sound Publishing, Inc. had no role in the preparation of this post. The views and opinions expressed in this sponsored post are those of the advertiser and do not reflect those of Sound Publishing, Inc.

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